High serum prolactin was detected in 15 out of 110 azoospermic men (13%). Patients underwent hormone assays, sellar radiography, and testicular biopsy (histological and meiotic analyses). Three patients, with most elevated serum prolactin level, had spermatogenic arrest. Nine patients showed no spermatogenic activity on histological and meiotic preparations. Three patients had normal and decreased spermatogenesis and normal meiotic divisions. The patients with spermatogenic arrest and with preserved spermatogenic process were treated with bromocriptine. Spermatogram in two patients with preserved spermatogenic process was ascertained to nearly normal range, after the treatment. There was no specific histologic or meiotic lesion in azoospermic men.